The Science
Grounded in evidence, not hype
Rewind's approach is built on peer-reviewed research, validated biomarker science, and established clinical frameworks. We focus on what the evidence actually supports — and we are transparent about the limits of what we know.
Biomarkers
What we track, and why it matters
Rewind monitors over fifty biomarkers across six key categories. Each marker is selected based on its established association with ageing, disease risk, and overall healthspan.
Metabolic Health
Fasting glucose, HbA1c, insulin, triglycerides, HOMA-IR
Metabolic markers provide insight into how your body processes energy and regulates blood sugar. Dysregulated metabolism is one of the earliest and most modifiable drivers of accelerated ageing.
Cardiovascular Function
Lipid panel, ApoB, Lp(a), hs-CRP, homocysteine
Cardiovascular biomarkers help assess your heart and vascular health. Many of these markers are measurable years before symptoms appear, making early detection a powerful tool for prevention.
Hormonal Balance
Testosterone, oestradiol, DHEA-S, cortisol, thyroid panel
Hormones regulate a vast range of bodily functions. Tracking hormonal patterns over time may help identify imbalances that are associated with accelerated ageing or reduced quality of life.
Inflammation & Immunity
hs-CRP, IL-6, ferritin, white cell differential, ESR
Chronic low-grade inflammation — sometimes called inflammageing — is linked to many age-related conditions. Monitoring inflammatory markers is intended to help identify and address these patterns early.
Organ Function
Liver enzymes (ALT, AST, GGT), kidney function (eGFR, creatinine), albumin
Organ function markers offer a window into how well your liver, kidneys, and other vital systems are performing. Subtle changes over time can signal areas that may benefit from attention.
Nutritional Status
Vitamin D, B12, folate, iron studies, magnesium, zinc
Micronutrient levels influence energy, cognition, immune function, and recovery. Targeted supplementation based on measured deficiencies is generally more effective than guesswork.
Biological Age
Your calendar age tells one story. Your biology may tell another.
Biological age is a composite measure designed to estimate how your body is ageing at a physiological level — independent of how many birthdays you have had. It draws on blood biomarkers, metabolic health indicators, cardiovascular fitness data, and other clinically validated inputs.
Research suggests that biological age may be a more meaningful predictor of health outcomes than calendar age alone. Two people born in the same year can have very different biological ages depending on genetics, lifestyle, environment, and health history.
Importantly, unlike calendar age, biological age appears to be modifiable. Targeted interventions in nutrition, exercise, sleep, and stress management have been associated with measurable reductions in biological age in published research.
How It Is Calculated
Rewind's biological age model uses a weighted analysis of your blood biomarkers, wearable-derived fitness metrics, body composition data, and lifestyle factors. The algorithm is informed by published epigenetic clock research and validated against population-level health outcome data.
50+
Biomarkers analysed
12mo
Tracking cycles
What It Means For You
Your biological age is not a diagnosis — it is a data point designed to inform your health strategy. A biological age lower than your calendar age may suggest your current habits are supporting healthy ageing. A higher biological age may highlight areas where targeted changes could help.
Longitudinal Data
Why ongoing measurement matters
A single snapshot of your health tells you where you are today. Longitudinal tracking reveals where you are heading — and whether your interventions are working.
Trend Detection
Individual biomarker readings can fluctuate day to day. What matters clinically is the trend over time. Rewind tracks your results across months and years, surfacing patterns that a single test would miss — such as a gradual rise in inflammatory markers or a slow decline in vitamin D levels.
Intervention Feedback
When you make a change — adjusting your diet, starting a new supplement, or modifying your exercise routine — longitudinal tracking is designed to show whether that change is having the intended effect. This creates a feedback loop that helps you and your clinician refine your plan with confidence.
Early Warning Signals
Many health conditions develop gradually over years before becoming symptomatic. Longitudinal biomarker tracking is intended to help identify these slow-moving changes early, when they may still be addressable through lifestyle modification or clinical intervention.
Personalised Baselines
Population reference ranges tell you what is "normal" for the average person. Longitudinal tracking establishes what is normal for you. This personalised baseline makes it easier to detect meaningful deviations — even when your results fall within standard ranges.
Prevention First
Prevention is more powerful than reaction
Traditional healthcare is largely reactive — designed to diagnose and treat conditions after they develop. While this approach is essential, it often intervenes at a stage where damage has already occurred and options are more limited.
Rewind is built on the principle that earlier is better. Research consistently shows that many of the leading causes of morbidity and mortality — cardiovascular disease, type 2 diabetes, metabolic syndrome — have modifiable risk factors that can be detected and addressed years before clinical symptoms appear.
Our platform is designed to support this preventive approach by combining regular biomarker monitoring, wearable data analysis, and AI-driven risk assessment — all reviewed by qualified clinicians.
Reactive Model
- Symptoms appear first, testing follows
- Conditions diagnosed after progression
- Interventions at a later stage
- Limited personalisation
Preventive Model (Rewind)
- Regular monitoring detects changes early
- Risk factors addressed before symptoms
- Ongoing data-driven optimisation
- Personalised to your unique biology
AI-Informed Insights
How artificial intelligence supports your health
Rewind uses AI to analyse complex, multi-dimensional health data and surface personalised insights. The AI is a tool — not a replacement for clinical judgement.
Pattern Recognition
Our AI analyses relationships across your biomarkers, wearable data, and health history to identify patterns that may not be obvious from individual data points alone.
Prioritised Insights
Rather than overwhelming you with data, the AI is designed to surface the most impactful areas for attention — helping you focus on changes that may have the greatest effect.
Continuous Refinement
Your health plan is not static. As new data flows in from blood work, wearables, and check-ins, the AI recalibrates its recommendations to reflect your current state.
Evidence-Linked Suggestions
Recommendations are grounded in peer-reviewed research and established clinical guidelines. The AI does not speculate — it draws on validated associations between interventions and outcomes.
Transparent Reasoning
Rewind shows you why a recommendation was made — which biomarkers informed it, what research supports it, and what outcome it is intended to support. No black-box advice.
Safety Guardrails
The AI operates within defined clinical boundaries. It does not recommend prescription medications, diagnose conditions, or suggest interventions outside established safety parameters.
Plan Validation
Every AI-generated health plan is reviewed by a qualified clinician before it reaches you. They check for safety, clinical appropriateness, drug interactions, and alignment with your medical history.
Clinical Context
AI excels at pattern recognition across large datasets. But clinical medicine requires context, judgement, and experience that algorithms cannot replicate. Our clinicians bring that human layer to every plan.
Ongoing Consultations
Your relationship with your Rewind clinician is not a one-off. They review your progress over time, adjust recommendations based on new results, and provide guidance as your health journey evolves.
Complementary Care
Rewind does not replace your GP or specialist. Our clinicians work alongside your existing healthcare providers, focusing specifically on prevention, longevity, and health optimisation.
Clinician Oversight
AI generates the insights. Doctors ensure they are right.
We believe that AI and clinical expertise are most powerful when they work together. Our AI handles the data-intensive analysis — processing thousands of data points across your biomarkers, wearables, and health history. But every recommendation passes through a human clinician before it reaches you.
This is not a formality. Clinician review is a core part of the Rewind model. Our doctors bring contextual understanding, clinical experience, and professional accountability that technology alone cannot provide.
The result is a health plan that combines the analytical power of AI with the safety and nuance of clinical medicine.
A note on our approach
Longevity science is a rapidly evolving field. While many of the biomarkers and interventions we use are supported by published research, the science is not settled on every question. We are committed to updating our models and recommendations as new evidence emerges.
Rewind is designed to support your health journey — not to diagnose, treat, or cure any disease. Our platform is intended to inform and empower, always in partnership with qualified clinicians. If you have a medical concern, please consult your doctor.
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Join Rewind and get a personalised, clinician-reviewed health plan built on your unique data. Science-backed insights, designed to support a longer, healthier life.